2023

McCaslin PN, Andersen SE, Icardi CM, Faris R, Steiert B, Smith P, Haider J, Weber MM. Identification and Preliminary Characterization of Novel Type III Secreted Effector Proteins in Chlamydia trachomatis. Infect Immun. 2023 Jul 18;91(7):e0049122. doi: 10.1128/iai.00491-22.

Steiert B, Icardi CM, Faris R, McCaslin PN, Smith P, Klingelhutz AJ, Yau PM, Weber MM. The Chlamydia trachomatis type III-secreted effector protein CteG induces centrosome amplification through interactions with centrin-2. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2303487120. doi: 10.1073/pnas.2303487120.

Steiert B, Faris R, Weber MM. In Search of a Mechanistic Link between Chlamydia trachomatis-Induced Cellular Pathophysiology and Oncogenesis. Infect Immun. 2023 Feb 16;91(2):e0044322. doi: 10.1128/iai.00443-22.

2022

Steiert B, Icardi C, Faris R, Klingelhutz K, Yau P, Weber MM. The Chlamydia trachomatis type III secreted effector protein CteG induces centrosome amplification through interactions with centrin-2. bioRxiv https://doi.org/10.1101/2022.06.23.496711

2021

Adcox HE, Hatke AL, Andersen SE, Gupta S, Otto NB, Weber MM, Marconi RT, Carlyon JA.Orientia tsutsugamushi Nucleomodulin Ank13 Exploits the RaDAR Nuclear Import Pathway To Modulate Host Cell Transcription. mBio. Aug 3:e0181621.

Andersen SE, Bulman LM, Steiert B, Faris R, Weber MM. Got mutants? How advances in chlamydial genetics have furthered the study of effector proteins. Pathog Dis. Feb 4;79(2):ftaa078. doi: 10.1093/femspd/ftaa078.

2020

Faris R, McCullough A, Andersen SE, Moninger TO, Weber MM. The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion. PLoS Pathog. Sep 18;16(9):e1008878. doi: 10.1371/journal.ppat.1008878.

Shima K, Weber MM, Schnee C, Sachse K, Käding N, Klinger M, Rupp J. Development of a Plasmid Shuttle Vector System for Genetic Manipulation of Chlamydia psittaci. mSphere. Aug 26;5(4):e00787-20. doi: 10.1128/mSphere.00787-20.

2019

Faris, R.,  Andersen, S., McCullough, A., Gourronc F., Klingelhutz A., Weber MM. Chlamydia trachomatis serovars drive differential production of proinflammatory cytokines and chemokines depending on the type of cell infected. Front. Cell Infect. Microbiol. Nov 26;9:399. doi: 10.3389/fcimb.2019.00399.

Faris R, Weber MM. Propagation and Purification of Chlamydia trachomatis Serovar L2 Transformants and Mutants. Bio Protoc. Dec 20;9(24):e3459. doi: 10.21769/BioProtoc.3459.

Faris R, Weber MM. Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens. J Vis Exp. Oct 25;(152). doi: 10.3791/60488

Weber MM, Faris R. Mutagenesis of Chlamydia trachomatis Using TargeTron. Methods Mol Biol. 2042:165-184.

Faris R, Merling M, Andersen SE, Dooley CA, Hackstadt T, Weber MM. Chlamydia trachomatis CT229 subverts Rab GTPase dependent CCV trafficking pathways to promote chlamydial infection.  Cell Reports. 19;26(12):3380-3390

2018

Weber MM and Faris R. Subversion of the endocytic and secretory pathways by bacterial effector proteins.  Frontiers Cell Dev. Biol. Membrane Traffic. 6:10.3389/fcell.2018.00001

Weber MM, Faris R., van Schaik EJ, Samuel JE. Identification and characterization of arginine finger-like motifs, and endosome-lysosome-basolateral sorting signals within ectopically expressed CirA, a Coxiella burnetii type IV secreted effector protein. Microbes Infect. 20: 10.1016/j.micinf.2017.12.013                                                                                                                                                          

2017

Weber MM, Lam J, Noriea NF, Dooley CA, Hansen BT, Hoyt FH, Carmady AB, Sager J, Sturdevant GL, Hackstadt. Chlamydia trachomatis inclusion membrane proteins are required for inclusion membrane stability and prevent host cell death. Cell Reports 16:1406-1417.

Wesolowski J, Weber MM, Maalouf AN, McCauley M, Cherfils J. Paumet F. Pathogenic control of microtubule stability through ARF GTPases. mBio 2: e02280-16.

Weber MM, Faris R, van Schaik EJ, Roman VA, McLachlan J, Wright WU, Tellez A, Di Russo Case E Luo ZQ, Samuel JE. The type IV secreted effector protein CirA stimulates the GTPase activity of RhoA and is required for virulence in a mouse model of Coxiella burnetii infection. Infect. Immun. 84: 2524-33.

2016

Weber MM, Noriea NF, Bauler LD, Lam J, Sager J, Wesolowski J, Paumet F, Hackstadt T. A functional core of IncA is required for Chlamydia trachomatis inclusion fusion. J. Bacteriol. 198: 1347-55.

Weber MM, Faris R, Tellez A, Wright WU, Galvan G, Luo ZQ, Samuel JE. Modulation of the host transcriptome by Coxiella burnetii nuclear effector, Cbu1314. Microbes Infect. 18: 336-45.

Faris R, Weber MM, Seegier D., Cavazos D, deGraffenried L, Murphy EJ, Jolly CA. Mitochondrial glycerol-3-phosphate acyltransferase dependent phospholipid synthesis modulates phospholipid mass and IL-2 production in Jurkat T cells. Lipids. 51: 291-301.

2015

Weber MM, Bauler LD, Lam J,Hackstadt T. Expression and localization of predicted inclusion membrane proteins in Chlamydia trachomatis. Infect. Immun. 83: 4710-8.

Weber MM Chen C, Rowin K, Mertens K, Galvan G, Zhi H, Dealing CM, Roman VA, Banga S, Tan Y, Luo ZQ, Samuel JE. Identification of Coxiella burnetii type four secretion substrates required for intracellular replication and Coxiella-containing vacuole formation. J. Bacteriol. 195(17): 3914-3924.

2013

van Schaik EJ, Chen C, Mertens K, Weber MM, Samuel JE. Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii. Nature Rev. Microbiol. 11: 561-573.

2012

Chu W, Zere TR, Weber MM, Wood TK, Whiteley M, Hidalgo-Romaino B, Valenzuela E, McLean RJC. Indole production promotes Escherichia coli mixed culture growth with Pseudomonas aeruginosa by inhibiting quorum signaling. Appl. Environ. Microbiol. 78(2): 411-419.

2010

Chen C, Banga S, Mertens K, Weber MM, Gorbaslieva I, Tan Y, Luo ZQ, Samuel JE. Large-scale identification of type IV secretion substrates by Coxiella burnetii. Proc. Nat. Acad. Sciences. 107(50): 21755-21760.

Weber MM, French CL, Barnes MB, Siegele DA, McLean RJ.  A previously uncharacterized gene, yjfo (bsmA), influences Escherichia coli biofilm formation and stress response. Microbiol. 156: 139-147.

Rahman P, Dusane D, Zinjarde S, Venugopalan V, McLean R, Weber M. Quorum sensing: implications on rhamolipid biosurfactant production. Biotechnol. Genetic Eng. Rev. 27: 159-181.